biology & Light

Neomedlight, The Fabric of Light for Phototherapy
Section : Phototherapy and Bilirubin conversion

PHOTOTHERAPY AND BILIRUBIN CONVERSION

Clinically proven over the years, Phototherapy is the standard treatment for hyperbilirubinemia. Phototherapy used to treat hyperbilirubinemia is characterized by emission of a light with a specific wavelength. Blue light, in the range of bilirubin absorption is able to reduce the (unconjugated) bilirubin level in the blood.

The efficacy of phototherapy units varies widely with light sources and types of configuration. The following characteristics of a device contribute to its effectiveness:

  • Emission of light in the blue range that best matches in vivo Bilirubin absorption (430–490 nm); 
  • Irradiance greater than 30 µW/cm²/nm characterizing intensive phototherapy which is considered to be particularly effective; 
  • Maximal body surface exposed to light. 

A variety of light sources are available with various effectiveness: fluorescent, tungsten, and halogen lamps, LEDs (light-emitting diodes). LEDs have changed the treatment approach thanks to their low heat output that reduce the newborn water loss and reduce the risk of hyperthermia. This technology allows also to deliver a better targeted wavelength, with a peak that specifically matches with the bilirubin absorption spectrum (460nm).

Section : Photobiomodulation

PHOTOBIOMODULATION

The Photobiomodulation is a process that causes biological modifications in organisms due to photon interaction with atoms and molecules. The treatment is conducted with red or near infrared light. This treatment is non-invasive and non-thermal.

This process results in beneficial therapeutic outcomes including the reduction of inflammation, analgesic effect and tissue regeneration.

Multiple clinical studies have demonstrated its interest in a vast scope of clinical applications (physiotherapy, oncology, dermatology…).

Section : Photodynamic Therapy

PHOTODYNAMIC THERAPY

Photodynamic therapy (PDT), sometimes called photochemotherapy, is a form of phototherapy involving light and a photosensitizing chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity).
PDT has proven ability to kill microbial cells, including bacteria, fungi and viruses. It is recognized as a treatment strategy that is both minimally invasive and minimally toxic.
Section : Other Actions of Light

OTHER ACTIONS OF LIGHT

Numerous other applications of light are described in the literature from cell destruction (with high power light sources) to circadian rhythm management.